We present a unified picture for the evolution of star clusters on the two-body relaxation timescale. We use direct N-body simulations of star clusters in a galactic tidal field starting from different multi-mass King models, up to 10% of primordial binaries and up to N(tot) = 65536 particles. An additional run also includes a central Intermediate Mass Black Hole. We find that for the broad range of initial conditions we have studied the stellar mass function of these systems presents a universal evolution which depends only on the fractional mass loss. The structure of the system, as measured by the core to half mass radius ratio, also evolves toward a universal state, which is set by the efficiency of heating on the visible population of stars induced by dynamical interactions in the core of the system. Interactions with dark remnants are dominant over the heating induced by a moderate population of primordial binaries (3-5%), especially under the assumption that most of the neutron stars and black holes are retained in the system. All our models without primordial binaries undergo a deep gravothermal collapse in the radial mass profile. However their projected light distribution can be well fitted by medium concentration King models (with parameter W0 ~ 8), even though there tends to be an excess over the best fit for the innermost points of the surface brightness. This excess is consistent with a shallow cusp in the surface brightness (μ(R) ~ R-v with v ~ 0.4-0.7), like it has been observed for many globular clusters from high-resolution HST imaging. Classification of core-collapsed globular clusters based on their surface brightness profile is likely to fail in systems that have already bounced back to lower concentrations.